Defamiliarization is one of the achievements of the Russian school of formalism that implies the alienation of the ordinary norm of the language. In the early twentieth century, a new and independent knowledge was created which dealt with the alienation of norms and defamiliarization. The Holy Qur'an, as the ever-lasting miracle of the Prophet of Islam (PBUH), has many literary beauties and is a perfect example of speech at the height of eloquence and rhetoric usage. In this sense, a precise and complete understanding of this divine book can be developed by referring to the various interpretations and translations of scholars in the field of Quranic sciences. In this study, in order to explain the literary miracle of the Holy Quran, we made an effort to study the theory of defamiliarization from the syntactic and rhetorical point of view and describe the examined aspects by a descriptive-analytical method in the holy Surah An-Naba. The result of the research shows that the constructive elements such as known and unknown phrases and the use of precedency and delays, omissions, references, attention, repetition and parenthetical phrases are among the post-modern samples of highlighting in these holy verses.